Technical Title: “Immunodominance Study in Polyvalent Vaccines Used in Salmon: a Tool for Redesigning and Improving Vaccines”.
Conventional Title: Generating Efficient and Effective Vaccines for the Prevention of Pathogen-Provoked Scepticaemia and Pancreatitis in Salmon.
- Directora: Dra. Mónica Imarai
General Objective (Technical Description): Creating vaccines without interfering antigens.
Description: The project team has successfully identified Piscirickettsia salmonisproteins which provoke protective responses to salmonid rickettsial septicaemia (SRS) and bacterial proteins that inhibit the fish’s immune response or deplete their defenses.
This is the first time that the proteins of P. salmonis which antagonize the fish’s immune response are identified. The application of this information in the design and redesign of the vaccines used in aquaculture could have powerful effects on the control of SRS that damages the Chilean farmed salmon production.
Status: A prototype of a vaccine based on this new knowledge is expected to be available in June 2019.
Project Benefits: The new vaccine will lower the incidence of SRS and therefore the use of antibiotics in the national salmon production, leading to a better environmental care. It will also have a positive economic impact, reducing treatment costs and production losses in the final farming stages. The same strategy may be applied to the design and redesign of other vaccines used in the fish industry.
